Glial ER and GAP junction mediated Ca²⁺ waves are crucial to maintain normal brain excitability.

ABSTRACT: Astrocytes play key roles in regulating multiple aspects of neuronal function from invertebrates to humans and display Ca²⁺ fluctuations that are heterogeneously distributed throughout different cellular microdomains. Changes in Ca²⁺ dynamics represent a key mechanism for how astrocytes modulate neuronal activity. An unresolved issue is the origin and contribution of specific glial Ca²⁺ signaling components at distinct astrocytic domains to neuronal physiology and brain function. The Drosophila model system offers a simple nervous system that is highly amenable to cell-specific genetic manipulations to characterize the role of glial Ca²⁺ signaling. Here we identify a role for ER store-operated Ca²⁺ entry (SOCE) pathway in perineurial g

SUBMITTER: Weiss S 

PROVIDER: S-EPMC9070121 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature