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New α-pyrones from an endophytic fungus, Hypoxylon investiens J2.

ABSTRACT: Four new α-pyrones, hypotiens A-D (1-4), were isolated from a fungal endophyte, Hypoxylon investiens J2, harbored in the medicinal plant Blumea balsamifera. Their structures were determined through detailed HRMS and NMR spectroscopic data. Compounds 1-4 are new α-pyrone derivatives containing an unusual dimethyl substitution in the highly unsaturated side chain. Their plausible biosynthetic pathway was discussed. Biological assay indicated that compounds 1-4 showed no antimicrobial, quorum sensing inhibitory, and cytotoxic activities. The specific side chain in α-pyrone derivatives 1-4 might be responsible for the weak pharmacological activities.

SUBMITTER: Yuan C

PROVIDER: S-EPMC9070768 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature

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New α-pyrones from an endophytic fungus, Hypoxylon investiens J2.

Yuan Chao C Yang Hong-Xia HX Guo Yu-Hua YH Fan Lin L Zhang Ying-Bo YB Li Gang G

RSC advances 20190801 47

Four new α-pyrones, hypotiens A-D (1-4), were isolated from a fungal endophyte, Hypoxylon investiens J2, harbored in the medicinal plant Blumea balsamifera. Their structures were determined through detailed HRMS and NMR spectroscopic data. Compounds 1-4 are new α-pyrone derivatives containing an unusual dimethyl substitution in the highly unsaturated side chain. Their plausible biosynthetic pathway was discussed. Biological assay indicated that compounds 1-4 showed no antimicrobial ...[more]

PMID: 35529215

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