Ontology highlight
ABSTRACT:
SUBMITTER: Tibely G
PROVIDER: S-EPMC9071171 | biostudies-literature | 2022 Apr
REPOSITORIES: biostudies-literature
Tibély Gergely G Schrempf Dominik D Derényi Imre I Szöllősi Gergely J GJ
PLoS computational biology 20220425 4
Tumors often harbor orders of magnitude more mutations than healthy tissues. The increased number of mutations may be due to an elevated mutation rate or frequent cell death and correspondingly rapid cell turnover, or a combination of the two. It is difficult to disentangle these two mechanisms based on widely available bulk sequencing data, where sequences from individual cells are intermixed and, thus, the cell lineage tree of the tumor cannot be resolved. Here we present a method that can sim ...[more]