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Regio- and enantioselective remote hydroarylation using a ligand-relay strategy.

ABSTRACT: The design of a single complicated chiral ligand to well-promote each step of an asymmetric cascade reaction is sometimes a formidable challenge in transition metal catalysis. In this work, a highly regio- and enantioselective Ni-catalysed migratory hydroarylation relay process has been achieved with the combination of two simple ligands, one which accomplishes chain-walking and the other causing asymmetric arylation. This formal asymmetric C(sp³)-H arylation provides direct access to a wide range of structurally diverse chiral 1,1-diarylalkanes, a structural unit found in a number of bioactive molecules. The value of this strategy was further demonstrated by the Ni-catalysed migratory asymmetric 1,3-arylboration.

SUBMITTER: He Y

PROVIDER: S-EPMC9072428 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature

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Regio- and enantioselective remote hydroarylation using a ligand-relay strategy.

He Yuli Y Ma Jiawei J Song Huayue H Zhang Yao Y Liang Yong Y Wang You Y Zhu Shaolin S

Nature communications 20220505 1

The design of a single complicated chiral ligand to well-promote each step of an asymmetric cascade reaction is sometimes a formidable challenge in transition metal catalysis. In this work, a highly regio- and enantioselective Ni-catalysed migratory hydroarylation relay process has been achieved with the combination of two simple ligands, one which accomplishes chain-walking and the other causing asymmetric arylation. This formal asymmetric C(sp<sup>3</sup>)-H arylation provides direct access to ...[more]

PMID: 35513385

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