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Mesoporous PbO nanoparticle-catalyzed synthesis of arylbenzodioxy xanthenedione scaffolds under solvent-free conditions in a ball mill.

ABSTRACT: A protocol for the efficient synthesis of arylbenzodioxy xanthenedione scaffolds was developed via a one-pot multi-component reaction of aromatic aldehydes, 2-hydroxy-1,4-naphthoquinone, and 3,4-methylenedioxy phenol using mesoporous PbO nanoparticles (NPs) as a catalyst under ball milling conditions. The synthesis protocol offers outstanding advantages, including short reaction time (60 min), excellent yields of the products (92-97%), solvent-free conditions, use of mild and reusable PbO NPs as a catalyst, simple purification of the products by recrystallization, and finally, the use of a green process of dry ball milling.

SUBMITTER: Lambat TL

PROVIDER: S-EPMC9072651 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature

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Mesoporous PbO nanoparticle-catalyzed synthesis of arylbenzodioxy xanthenedione scaffolds under solvent-free conditions in a ball mill.

Lambat Trimurti L TL Chaudhary Ratiram G RG Abdala Ahmed A AA Mishra Raghvendra Kumar RK H Mahmood Sami S Banerjee Subhash S

RSC advances 20190930 54

A protocol for the efficient synthesis of arylbenzodioxy xanthenedione scaffolds was developed <i>via</i> a one-pot multi-component reaction of aromatic aldehydes, 2-hydroxy-1,4-naphthoquinone, and 3,4-methylenedioxy phenol using mesoporous PbO nanoparticles (NPs) as a catalyst under ball milling conditions. The synthesis protocol offers outstanding advantages, including short reaction time (60 min), excellent yields of the products (92-97%), solvent-free conditions, use of mild and reusable PbO ...[more]

PMID: 35527919

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