Identification of heritable rare variants associated with early-stage lung adenocarcinoma risk.

ABSTRACT:

Background

In East Asia, the number of patients with adenocarcinoma, especially those presenting with ground-glass nodules (GGNs), is gradually increasing. Family aggregation of pulmonary GGNs is not uncommon; however, genetic predisposition in these patients remains poorly understood and identification of genes involved in the cause of these early-stage lung cancers might contribute to understanding of the underlying mechanisms and potential prevention strategies.

Methods

Fifty patients with early-stage lung adenocarcinoma (LUAD) presenting as GGNs and a first-degree family history of lung cancer (FHLC) from 34 independent families were enrolled into this study. Germline mutations of these patients were analyzed with whole exome sequencing (WES) and compared with age- and s

SUBMITTER: Fu R 

PROVIDER: S-EPMC9073742 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature