Mitral Valve Prolapse Induces Regionalized Myocardial Fibrosis.

ABSTRACT: Background Mitral valve prolapse (MVP) is one of the most common forms of cardiac valve disease and affects 2% to 3% of the population. Previous imaging reports have indicated that myocardial fibrosis is common in MVP and described its association with sudden cardiac death. These data combined with evidence for postrepair ventricular dysfunction in surgical patients with MVP support a link between fibrosis and MVP. Methods and Results We performed histopathologic analysis of left ventricular (LV) biopsies from peripapillary regions, inferobasal LV wall and apex on surgical patients with MVP, as well as in a mouse model of human MVP (Dzip1^S14R/+). Tension-dependent molecular pathways were subsequently assessed using both computational modeling and cyclica

SUBMITTER: Morningstar JE 

PROVIDER: S-EPMC9075228 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature