Electrospun acellular scaffolds for mimicking the natural anisotropy of the extracellular matrix.

ABSTRACT: In tissue engineering, the use of scaffolds helps establish a synergistic relationship between the scaffolds and the tissues by improving cell-scaffold interaction. This interaction is enhanced when physiologically relevant biophysical cues are replicated in the artificial scaffolds. Here, we present a novel scaffold that mimics the natural anisotropy of the native extracellular matrix of tissues, fabricated by electrospinning a combination of three polymers: polycaprolactone (PCL), polyvinylidene fluoride (PVDF) and polyaniline (PANI). The scaffolds were characterized for their morphology, surface and mechanical properties. Rat cardiomyoblast (H9c2) cells, cultured on the PCL-PANI-PVDF scaffold, demonstrated cell alignment, penetration and proliferation across the entire surface area of t

SUBMITTER: Nagam Hanumantharao S 

PROVIDER: S-EPMC9076170 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature