Hippocampal place codes are gated by behavioral engagement.
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ABSTRACT:
SUBMITTER: Pettit NL
PROVIDER: S-EPMC9076532 | biostudies-literature | 2022 May
REPOSITORIES: biostudies-literature
Publications
Hippocampal place codes are gated by behavioral engagement.
Pettit Noah L NL Yuan Xintong C XC Harvey Christopher D CD
Nature neuroscience 20220421 5
As animals explore an environment, the hippocampus is thought to automatically form and maintain a place code by combining sensory and self-motion signals. Instead, we observed an extensive degradation of the place code when mice voluntarily disengaged from a virtual navigation task, remarkably even as they continued to traverse the identical environment. Internal states, therefore, can strongly gate spatial maps and reorganize hippocampal activity even without sensory and self-motion changes. ...[more]
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