Ontology highlight
ABSTRACT:
SUBMITTER: Takematsu E
PROVIDER: S-EPMC9076913 | biostudies-literature | 2022 May
REPOSITORIES: biostudies-literature
Takematsu Eri E Massidda Miles M Auster Jeff J Chen Po-Chih PC Im ByungGee B Srinath Sanjana S Canga Sophia S Singh Aditya A Majid Marjan M Sherman Michael M Dunn Andrew A Graham Annette A Martin Patricia P Baker Aaron B AB
Nature communications 20220506 1
Stem cell factor (SCF) is a cytokine that regulates hematopoiesis and other biological processes. While clinical treatments using SCF would be highly beneficial, these have been limited by toxicity related to mast cell activation. Transmembrane SCF (tmSCF) has differential activity from soluble SCF and has not been explored as a therapeutic agent. We created novel therapeutics using tmSCF embedded in proteoliposomes or lipid nanodiscs. Mouse models of anaphylaxis and ischemia revealed the tmSCF- ...[more]