Pharmacogenomics of in vitro response of the NCI-60 cancer cell line panel to Indian natural products.

ABSTRACT:

Background

Indian natural products have been anecdotally used for cancer treatment but with limited efficacy. To better understand their mechanism, we examined the publicly available data for the activity of Indian natural products in the NCI-60 cell line panel.

Methods

We examined associations of molecular genomic features in the well-characterized NCI-60 cancer cell line panel with in vitro response to treatment with 75 compounds derived from Indian plant-based natural products. We analyzed expression measures for annotated transcripts, lncRNAs, and miRNAs, and protein-changing single nucleotide variants in cancer-related genes. We also examined the similarities between cancer cell line response to Indian natural products and response to reference anti-tumor compounds reco

SUBMITTER: Sankaran H 

PROVIDER: S-EPMC9077913 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature