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Green synthesis of new pyrrolidine-fused spirooxindoles via three-component domino reaction in EtOH/H₂O.

ABSTRACT: An efficient, green and sustainable approach for the synthesis of novel polycyclic pyrrolidine-fused spirooxindole compounds was developed. The synthesis included a one-pot, three-component, domino reaction of (E)-3-(2-nitrovinyl)-indoles, isatins and chiral polycyclic α-amino acids under catalyst-free conditions at room temperature in EtOH-H₂O. The salient features of this methodology are eco-friendliness, high yields and the ease of obtaining target compounds without the involvement of toxic solvents and column chromatography. These novel polycyclic pyrrolidine-fused spirooxindoles provide a collection of structurally diverse compounds that show promise for future bioassays and medical treatments.

SUBMITTER: Wang YC

PROVIDER: S-EPMC9078157 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature

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Green synthesis of new pyrrolidine-fused spirooxindoles via three-component domino reaction in EtOH/H2O.

Wang Yong-Chao YC Wang Jun-Liang JL Burgess Kevin S KS Zhang Jiang-Wei JW Zheng Qiu-Mei QM Pu Ya-Dan YD Yan Li-Jun LJ Chen Xue-Bing XB

RSC advances 20180202 11

An efficient, green and sustainable approach for the synthesis of novel polycyclic pyrrolidine-fused spirooxindole compounds was developed. The synthesis included a one-pot, three-component, domino reaction of (E)-3-(2-nitrovinyl)-indoles, isatins and chiral polycyclic α-amino acids under catalyst-free conditions at room temperature in EtOH-H2O. The salient features of this methodology are eco-friendliness, high yields and the ease of obtaining target compounds without the invo ...[more]

PMID: 35539589

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