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Facile synthesis of α-alkoxyl amides via scandium-catalyzed oxidative reaction between ynamides and alcohols.

ABSTRACT: A novel and efficient scandium-catalyzed oxidative reaction between ynamides and alcohols for the facile synthesis of various α-alkoxyl amides is reported in this paper. The reaction avoids the need for the use of α-diazo carbonyls which are unstable and may cause some safety concerns. Instead, by using alkynes as the starting materials, this protocol features readily available substrates, compatibility with a broad range of functional groups, simple procedure, mild reaction conditions, and high chemoselectivity.

SUBMITTER: Zhang ZX

PROVIDER: S-EPMC9080523 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature

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Facile synthesis of α-alkoxyl amides <i>via</i> scandium-catalyzed oxidative reaction between ynamides and alcohols.

Zhang Zhi-Xin ZX Zhu Bo-Han BH Xie Pei-Xi PX Tang Jia-Qi JQ Li Xin-Ling XL Zhu Chunyin C Yin Ying-Wu YW Ye Long-Wu LW

RSC advances 20180518 33

A novel and efficient scandium-catalyzed oxidative reaction between ynamides and alcohols for the facile synthesis of various α-alkoxyl amides is reported in this paper. The reaction avoids the need for the use of α-diazo carbonyls which are unstable and may cause some safety concerns. Instead, by using alkynes as the starting materials, this protocol features readily available substrates, compatibility with a broad range of functional groups, simple procedure, mild reaction conditions, and high ...[more]

PMID: 35541116

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