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Synthesis of diversely substituted bis-pyrrolizidino/ thiopyrrolizidino oxindolo/acenaphthyleno curcuminoids via sequential azomethine ylide cycloaddition.

ABSTRACT: Curcumin has been transformed to several diversely substituted bis-pyrrolizidino/thiopyrrolizidino oxindolo/acenaphthyleno curcuminoids via a sequential azomethine ylide cycloaddition reaction using isatins/acenaphthoquinone and proline/thioproline as the reagents. The products were separated via extensive chromatography and characterized by 1D/2D NMR and HRMS analysis.

SUBMITTER: Singh M 

PROVIDER: S-EPMC9080697 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature

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Synthesis of diversely substituted bis-pyrrolizidino/ thiopyrrolizidino oxindolo/acenaphthyleno curcuminoids <i>via</i> sequential azomethine ylide cycloaddition.

Singh Meenakshi M   Hazra Abhijit A   Bharitkar Yogesh P YP   Kalia Ritu R   Sahoo Ashutosh A   Saha Sneha S   Ravichandiran V V   Ghosh Shekhar S   Mondal Nirup B NB  

RSC advances 20180523 34

Curcumin has been transformed to several diversely substituted bis-pyrrolizidino/thiopyrrolizidino oxindolo/acenaphthyleno curcuminoids <i>via</i> a sequential azomethine ylide cycloaddition reaction using isatins/acenaphthoquinone and proline/thioproline as the reagents. The products were separated <i>via</i> extensive chromatography and characterized by 1D/2D NMR and HRMS analysis. ...[more]

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