Association and pathways between shift work and cardiovascular disease: a prospective cohort study of 238 661 participants from UK Biobank.

ABSTRACT:

Background

This study aimed to study the association between shift work and incident and fatal cardiovascular disease (CVD), and to explore modifying and mediating factors.

Methods

This is a population-based, prospective cohort study with a median follow-up of 11 years; 238 661 UK Biobank participants who were in paid employment or self-employed at baseline assessment were included.

Results

Shift workers had higher risk of incident [hazard ratio (HR) 1.11, 95% confidence interval (CI) 1.06-1.19] and fatal (HR 1.25, 95% CI 1.08-1.44) CVD compared with non-shift workers, after adjusting for socio-economic and work-related factors. The risk was higher with longer duration of shift work, in women and in jobs with little heavy manual labour. Current smoking, short sleep du

SUBMITTER: Ho FK 

PROVIDER: S-EPMC9082805 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature