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Silver-catalyzed direct benzylation of acetanilide: a highly efficient approach to unsymmetrical triarylmethanes.

ABSTRACT: A highly efficient silver-catalyzed dibenzylation of acetanilides by employing the benzhydrol derivatives as the coupling partners to yield triphenylmethane derivatives has been developed. Various functional groups were tolerated, leading to the corresponding products in moderate to good yields. Preliminary experimental results indicated that the silver ions activate the arene rings and the strong acid TfOH provides the carbocations.

SUBMITTER: Li Y

PROVIDER: S-EPMC9085427 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature

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Silver-catalyzed direct benzylation of acetanilide: a highly efficient approach to unsymmetrical triarylmethanes.

Li Yuting Y Zhu Yan Y Tu Guangliang G Zhang Jingyu J Zhao Yingsheng Y

RSC advances 20180828 53

A highly efficient silver-catalyzed dibenzylation of acetanilides by employing the benzhydrol derivatives as the coupling partners to yield triphenylmethane derivatives has been developed. Various functional groups were tolerated, leading to the corresponding products in moderate to good yields. Preliminary experimental results indicated that the silver ions activate the arene rings and the strong acid TfOH provides the carbocations. ...[more]

PMID: 35546817

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