Genetic and phylogenetic uncoupling of structure and function in human transmodal cortex.

ABSTRACT: Brain structure scaffolds intrinsic function, supporting cognition and ultimately behavioral flexibility. However, it remains unclear how a static, genetically controlled architecture supports flexible cognition and behavior. Here, we synthesize genetic, phylogenetic and cognitive analyses to understand how the macroscale organization of structure-function coupling across the cortex can inform its role in cognition. In humans, structure-function coupling was highest in regions of unimodal cortex and lowest in transmodal cortex, a pattern that was mirrored by a reduced alignment with heritable connectivity profiles. Structure-function uncoupling in macaques had a similar spatial distribution, but we observed an increased coupling between structure and function in association cortices relati

SUBMITTER: Valk SL 

PROVIDER: S-EPMC9085871 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature