Spindle pole body component 25 in the androgen-induced regression of castration-resistant prostate cancer.

ABSTRACT:

Background

Androgen plays a critical role in the development and growth of prostate cancer (PCa) by binding to the androgen receptor, a steroid receptor for testosterone and dihydrotestosterone (DHT). Androgen deprivation therapy, a clinical endocrine therapy, has resulted in increases in the occurrence of castration-resistant prostate cancer (CRPC); however, the mechanisms of CRPC have not yet fully been determined. We previously showed that spindle pole body component 25 (SPC25), a component of the NDC80 complex that is critical in kinetochore formation and chromosome segregation during the cell cycle, plays a critical role in PCa tumorigenesis and cancer stemness. However, it is not yet known whether SPC25 plays a role in CRPC; thus, we sought to address this question in the cur

SUBMITTER: Cui F 

PROVIDER: S-EPMC9085928 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature