Improvement of Pain Management by Nefopam in a Rat Adjuvant-Induced Arthritis Model.

ABSTRACT:

Introduction

The adjuvant-induced arthritis (AIA) model is widely used in research to investigate arthritis pathogenesis. Hind paw inflammation is the main outcome in this model with high loss of mobility function partly related to pain. However, analgesics such as non-steroidal anti-inflammatory drugs or opioid drugs interfere with the inflammation process related to arthritis, thus reducing their beneficial use in this model. Therefore, we investigated the effect of nefopam on arthritis development in order to improve pain management in the AIA model.

Methods

Female Lewis rats were randomly divided into two groups, and each group received an injection of Mycobacterium butyricum on defining day (D) 0. At D6, rats (n = 10) received nefopam (intraperitoneally or

SUBMITTER: Dalix E 

PROVIDER: S-EPMC9087999 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature