Sex-associated differences between BMI and SARS-CoV-2 antibody titers following the BNT162b2 vaccine.

ABSTRACT:

Objective

This study investigated the sex-associated difference in the impact of obesity on antibody response to a COVID-19 vaccine.

Methods

This study included 2,435 health care workers who received two doses of the BioNTech, Pfizer (BNT162b2) vaccine and participated in a serological survey, during which they were tested for anti-SARS-CoV-2 spike immunoglobin G (IgG) antibodies and asked for information on height, weight, and vaccination history via a questionnaire. Multivariable linear regression analysis was used to estimate the geometric mean titers (GMT) of antibodies for each sex and BMI category.

Results

The relationship between BMI and anti-SARS-CoV-2 spike IgG titers markedly differed by sex (p value for interaction = 0.04). Spike IgG antibody titers tended

SUBMITTER: Yamamoto S 

PROVIDER: S-EPMC9088326 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature