Missense Variant rs28362680 in BTNL2 Reduces Risk of Coronary Heart Disease.

ABSTRACT:

Background

The pathological basis of coronary heart disease (CHD) is atherosclerosis. BTNL2 can inhibit the activation of T cells. We aimed to explore the association between BTNL2 genetic variants and CHD risk in the southern Chinese Han population.

Methods

We recruited 1419 participants to perform an association analysis between missense variants in BTNL2 and CHD risk through SNPStats online software. Genotyping of all candidate SNPs were completed by the Agena MassARRAY. In addition, we used false-positive report probability analysis to detect whether the positive findings were noteworthy observations. We also used Haploview 4.2 software and SNPStats online software to conduct the haplotype analysis and analysis of linkage disequilibrium (LD). Finally

SUBMITTER: Zhuo J 

PROVIDER: S-EPMC9091699 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature