Lignan Intake and Risk of Coronary Heart Disease.

ABSTRACT:

Background

Evidence regarding lignan consumption in relation to coronary heart disease (CHD) risk remains limited and mixed.

Objectives

The aim of this study was to prospectively examine associations between lignan intake and CHD risk in U.S. men and women.

Methods

We prospectively followed 214,108 men and women in 3 cohorts who did not have cardiovascular disease or cancer at baseline. Diet was repeatedly assessed using a validated food frequency questionnaire every 2-4 years since baseline.

Results

During 5,517,225 person-years of follow-up, we documented 10,244 CHD cases, including 6,283 nonfatal myocardial infarction and 3,961 fatal CHD cases. In multivariable-adjusted analyses, comparing extreme quintiles, the pooled hazard ratios of CHD were 0.85 (95% CI:

SUBMITTER: Hu Y 

PROVIDER: S-EPMC8432598 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature