Ontology highlight
ABSTRACT:
SUBMITTER: Silva-Cuevas C
PROVIDER: S-EPMC9092473 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Silva-Cuevas Carolina C Paleo Ehecatl E León-Rayo David F DF Lujan-Montelongo J Armando JA
RSC advances 20180710 43
A facile and highly efficient method for the bromomethylation of thiols, using paraformaldehyde and HBr/AcOH, has been developed, which advantageously minimizes the generation of highly toxic byproducts. The preparation of 22 structurally diverse α-bromomethyl sulfides illustrates the chemo-tolerant applicability while bromo-lithium exchange and functionalization sequences, free radical reductions, and additions of the title compounds demonstrate their synthetic utility. ...[more]