A bioactive phlebovirus-like envelope protein in a hookworm endogenous virus.
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ABSTRACT:
SUBMITTER: Merchant M
PROVIDER: S-EPMC9094657 | biostudies-literature | 2022 May
REPOSITORIES: biostudies-literature
Publications
A bioactive phlebovirus-like envelope protein in a hookworm endogenous virus.
Merchant Monique M Mata Carlos P CP Liu Yangci Y Zhai Haoming H Protasio Anna V AV Modis Yorgo Y
Science advances 20220511 19
Endogenous viral elements (EVEs), accounting for 15% of our genome, serve as a genetic reservoir from which new genes can emerge. Nematode EVEs are particularly diverse and informative of virus evolution. We identify Atlas virus-an intact retrovirus-like EVE in the human hookworm <i>Ancylostoma ceylanicum</i>, with an envelope protein genetically related to G<sub>N</sub>-G<sub>C</sub> glycoproteins from the family Phenuiviridae. A cryo-EM structure of Atlas G<sub>C</sub> reveals a class II viral ...[more]
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