A multistudy analysis reveals that evoked pain intensity representation is distributed across brain systems.

ABSTRACT: Information is coded in the brain at multiple anatomical scales: locally, distributed across regions and networks, and globally. For pain, the scale of representation has not been formally tested, and quantitative comparisons of pain representations across regions and networks are lacking. In this multistudy analysis of 376 participants across 11 studies, we compared multivariate predictive models to investigate the spatial scale and location of evoked heat pain intensity representation. We compared models based on (a) a single most pain-predictive region or resting-state network; (b) pain-associated cortical-subcortical systems developed from prior literature ("multisystem models"); and (c) a model spanning the full brain. We estimated model accuracy using leave-one-study-out cross-valida

SUBMITTER: Petre B 

PROVIDER: S-EPMC9098029 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature