Biochemical Investigation of Inhibitory Activities of Plant-Derived Bioactive Compounds Against Carbohydrate and Glucagon-Like Peptide-1 Metabolizing Enzymes.

ABSTRACT: The aim of current study was to investigate the inhibitory activities of resveratrol and taxifolin against α-amylase, α-glucosidase, and DPP-IV enzymes via in vitro analysis which was further validated by in silico studies. The analysis of molecular docking was also done to determine the binding capabilities of resveratrol and taxifolin with α-amylase, α-glucosidase, and DPP-IV enzymes. Resveratrol and taxifolin having IC₅₀ values, 47.93 ± 5.21 μM and 45.86 ± 3.78 μM , respectively, showed weaker effect than acarbose (4.6 ± 1.26 μM ) on α-amylase but showed significant effect to inhibit α-glucosidase (32.23 ± .556 μM and 31.26 ± .556 μM , respectively). IC₅₀ value of resveratrol and taxifolin (5.638 ± .0016 μM and 6.691 ± .004 μM ) in comparison t

SUBMITTER: Khalid MF 

PROVIDER: S-EPMC9099060 | biostudies-literature | 2022 Apr-Jun

REPOSITORIES: biostudies-literature