5-fluorouracil treatment of patient-derived scaffolds from colorectal cancer reveal clinically critical information.

ABSTRACT:

Background

Colorectal cancer is a commonly diagnosed cancer worldwide. Unfortunately, many patients do not respond to standard chemotherapy treatments and develop disease relapse and metastases. Besides cancer cell specific genetic changes, heterogeneity in the tumor microenvironment contribute to the clinical presentation of the disease and can potentially also influence drug resistance. By using a recently developed patient-derived scaffold method monitoring how a standardized reporter cancer cell line adapts to various microenvironments treated with chemotherapy, we wanted to clarify how individual patient specific microenvironments influence the chemotherapy response in colorectal cancer.

Methods

Surgically resected colorectal cancer specimens from 89 patients were decel

SUBMITTER: Salerno S 

PROVIDER: S-EPMC9102939 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature