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Synthesis and Photolytic Assessment of Nitroindolinyl-Caged Calcium Ion Chelators.

ABSTRACT: Neuroactive amino acids derivatised at their carboxylate groups with a photolabile nitroindolinyl group are highly effective reagents for the sub-µs release of neuroactive amino acids in physiological solutions. However, the same does not apply in the case of calcium ion chelators. In this study, nitroindolinyl-caged BAPTA is found to be completely photostable, whereas nitroindolinyl-caged EDTA photolyses only when saturated with calcium ions.

SUBMITTER: Papageorgiou G

PROVIDER: S-EPMC9104977 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature

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Synthesis and Photolytic Assessment of Nitroindolinyl-Caged Calcium Ion Chelators.

Papageorgiou George G Corrie John E T JET

Molecules (Basel, Switzerland) 20220420 9

Neuroactive amino acids derivatised at their carboxylate groups with a photolabile nitroindolinyl group are highly effective reagents for the sub-µs release of neuroactive amino acids in physiological solutions. However, the same does not apply in the case of calcium ion chelators. In this study, nitroindolinyl-caged BAPTA is found to be completely photostable, whereas nitroindolinyl-caged EDTA photolyses only when saturated with calcium ions. ...[more]

PMID: 35565996

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Project description:The photodissociation of small molecules has been extensively studied because of the increase in environmental problems related to the atmosphere of the Earth. In this work, the photodissociation mechanisms of hydroxylamine (NH2OH) as a model molecule in its lowest singlet-excited (S1) state were systematically studied using the complete active space second-order perturbation theory (CASPT2) and transition state theory (TST). In particular, this study focused on nonradiative relaxation processes that convert the S0 → S1 excited-state molecule to its products in their respective electronic ground states. The potential energy curves obtained from relaxed scans suggest that O-H dissociation is the preferred process in the S1 state. For the N-O and N-H dissociation pathways, thermally excited precursors were hypothesized to form in the S0 state to circumvent O-H dissociation. Thus, S0 → S1 vertical excitations lead to transition structures in the S1 state, which fragment to their respective electronic-ground-state products. The thermodynamic and kinetic results confirmed the precursor hypothesis, showing that the exothermic energy caused by the formation of HNO and H2 is sufficient to generate such precursors in the S0 state. Additionally, the TST confirmed that unimolecular isomerization-dissociation is a two-step process that generates products effectively by direct photolysis of the corresponding covalent bonds. In particular, the process consists of O-H bond dissociation, followed by spontaneous isomerization and formation of H2 in its electronic ground state, resulting in the high quantum yield observed in the UV absorption experiments in the preferential formation of HNO and H2. The configuration interaction coefficients of the characteristic structures on the potential energy curves revealed considerable changes in the multiconfigurational character of the wavefunctions, especially for the transition structures. These are characterized by the development of Rydberg orbitals, being produced at the intersection of the S0 and S1 states. The present study highlights the effects of thermal selectivity and the multiconfigurational character of the wavefunctions on photodissociation. Because detailed information on the photolytic mechanisms of isolated NH2OH is limited both theoretically and experimentally, these results provide fundamental insight into unimolecular photodissociation, posing ground for future studies on related systems.

Dataset Information

Synthesis and Photolytic Assessment of Nitroindolinyl-Caged Calcium Ion Chelators.

Publications

Synthesis and Photolytic Assessment of Nitroindolinyl-Caged Calcium Ion Chelators.

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