Treatment of Gastrointestinal Disorders-Plants and Potential Mechanisms of Action of Their Constituents.

ABSTRACT: The worldwide prevalence of gastrointestinal diseases is about 40%, with standard pharmacotherapy being long-lasting and economically challenging. Of the dozens of diseases listed by the Rome IV Foundation criteria, for five of them (heartburn, dyspepsia, nausea and vomiting disorder, constipation, and diarrhoea), treatment with herbals is an official alternative, legislatively supported by the European Medicines Agency (EMA). However, for most plants, the Directive does not require a description of the mechanisms of action, which should be related to the therapeutic effect of the European plant in question. This review article, therefore, summarizes the basic pharmacological knowledge of synthetic drugs used in selected functional gastrointestinal disorders (FGIDs) and correlates them wit

SUBMITTER: Czigle S 

PROVIDER: S-EPMC9105531 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature