Ontology highlight
ABSTRACT:
SUBMITTER: Cai Y
PROVIDER: S-EPMC9106008 | biostudies-literature | 2022 Apr
REPOSITORIES: biostudies-literature
Cai Yanpeng Y Zhang Wei W Lun Shichun S Zhu Tongtong T Xu Weijun W Yang Fan F Tang Jie J Bishai William R WR Yu Lifang L
Molecules (Basel, Switzerland) 20220429 9
Polyketide synthase 13 (Pks13), an essential enzyme for the survival of <i>Mycobacterium tuberculosis</i> (<i>Mtb</i>), is an attractive target for new anti-TB agents. In our previous work, we have identified 2-phenylindole derivatives against <i>Mtb</i>. The crystallography studies demonstrated that the two-position phenol was solvent-exposed in the Pks13-TE crystal structure and a crucial hydrogen bond was lost while introducing bulkier hydrophobic groups at indole <i>N</i> moieties. Thirty-si ...[more]