Crosstalk between epithelial sodium channels (ENaC) and basolateral potassium channels (K_ir 4.1/K_ir 5.1) in the cortical collecting duct.

ABSTRACT:

Background and purpose

Inwardly rectifying K⁺ (K_ir ) channels located on the basolateral membrane of epithelial cells of the distal nephron play a crucial role in K⁺ handling and BP control, making these channels an attractive target for the treatment of hypertension. The purpose of the present study was to determine how the inhibition of basolateral K_ir 4.1/K_ir 5.1 heteromeric K⁺ channel affects epithelial sodium channel (ENaC)-mediated Na⁺ transport in the principal cells of cortical collecting duct (CCD).

Experimental approach

The effect of fluoxetine, amitriptyline and recently developed K_ir inhibitor, VU0134992, on the activity of K_ir 4.1, K_ir 4.1/K_ir

SUBMITTER: Isaeva E 

PROVIDER: S-EPMC9106811 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature