Higher Serum Soluble TREM2 as a Potential Indicative Biomarker for Cognitive Impairment in Inadequately Controlled Type 2 Diabetes Without Obesity: The DOR-KyotoJ-1.

ABSTRACT:

Objective

Type 2 diabetes is a risk factor for dementia. We investigated whether serum levels of soluble triggering receptor expressed on myeloid cell 2 (sTREM2), a soluble form of the cell surface receptor TREM2, were predictive of cognitive impairment in type 2 diabetes without obesity.

Methods

A total of 166 Japanese patients with type 2 diabetes without obesity were followed-up for 2 years. We measured clinical parameters, assessed cognitive function using the mini-mental state examination (MMSE), quantified and divided serum sTREM2 levels into quartiles, and examined the longitudinal associations.

Results

During the follow-up, HbA_1c levels were elevated in 98 patients and decreased in 68 patients. In the HbA_1c-elevated group, higher sTREM2 l

SUBMITTER: Tanaka M 

PROVIDER: S-EPMC9110765 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature