Anti-Inflammatory, Antiallergic and COVID-19 Main Protease (M^pro) Inhibitory Activities of Butenolides from a Marine-Derived Fungus Aspergillus costaricaensis.

ABSTRACT: Amid the current COVID-19 pandemic, the emergence of several variants in a relatively high mutation rate (twice per month) strengthened the importance of finding out a chemical entity that can be potential for developing an effective medicine. In this study, we explored ethyl acetate (EtOAc) extract of a marine-derived fungus Aspergillus cosatricaensis afforded three butenolide derivatives, butyrolactones I, VI and V (1-3), two naphtho-γ-pyrones, TMC-256 A1 (4) and rubrofusarin B (5) and methyl p-hydroxyphenyl acetate (6). Structure identification was unambiguously determined based on exhaustive spectral analyses including 1D/2D NMR and mass spectrometry. The isolated compounds (1-6) were assessed for their in vitro anti

SUBMITTER: Uras IS 

PROVIDER: S-EPMC9111082 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature