Persistent olfactory dysfunction after COVID-19 is associated with reduced perfusion in the frontal lobe.

ABSTRACT:

Background

Olfactory dysfunction is common during SARS-CoV-2 infection. The pathophysiology of the persistence of this symptom and the potential relationship with central nervous system involvement is unknown.

Aim of the study

To evaluate the neural correlates of persistent olfactory dysfunction in a series of patients with post-COVID syndrome.

Methods

Eighty-two patients with post-COVID syndrome were assessed with the Brief Smell Identification Test and a multimodal MRI study including 3D-T1, T2-FLAIR, diffusion-tensor imaging, and arterial spin labeling. Olfactory and neuroimaging examinations were performed 11.18 ± 3.78 months after the acute infection. Voxel-based brain mapping analyses were conducted to correlate the olfactory test with brain volumes, white matte

SUBMITTER: Yus M 

PROVIDER: S-EPMC9111206 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature