Layer-specific pyramidal neuron properties underlie diverse anterior cingulate cortical motor and limbic networks.

ABSTRACT: The laminar cellular and circuit mechanisms by which the anterior cingulate cortex (ACC) exerts flexible control of motor and affective information for goal-directed behavior have not been elucidated. Using multimodal tract-tracing, in vitro patch-clamp recording and computational approaches in rhesus monkeys (M. mulatta), we provide evidence that specialized motor and affective network dynamics can be conferred by layer-specific biophysical and structural properties of ACC pyramidal neurons targeting two key downstream structures -the dorsal premotor cortex (PMd) and the amygdala (AMY). AMY-targeting neurons exhibited significant laminar differences, with L5 more excitable (higher input resistance and action potential firing rates) than L3 neurons. Between-pathway differences were found w

SUBMITTER: Medalla M 

PROVIDER: S-EPMC9113240 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature