Proteomic characterization of Aspergillus fumigatus isolated from air and surfaces of the International Space Station.

ABSTRACT: The on-going Microbial Observatory Experiments on the International Space Station (ISS) revealed the presence of various microorganisms that may be affected by the distinct environment of the ISS. The low-nutrient environment combined with enhanced irradiation and microgravity may trigger changes in the molecular suite of microorganisms leading to increased virulence and resistance of microbes. Proteomic characterization of two Aspergillus fumigatus strains, ISSFT-021 and IF1SW-F4, isolated from HEPA filter debris and cupola surface of the ISS, respectively, is presented, along with a comparison to well-studied clinical isolates Af293 and CEA10. In-depth analysis highlights variations in the proteome of both ISS-isolated strains when compared to the clinical strains. Proteins that showed i

SUBMITTER: Blachowicz A 

PROVIDER: S-EPMC9116463 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature