Utility of Biomarkers for Sepsis-Associated Acute Kidney Injury Staging.

ABSTRACT:

Importance

The 23rd Acute Disease Quality Initiative (ADQI-23) consensus conference proposed a framework to integrate biomarkers into the staging of acute kidney injury (AKI). It is unknown whether tissue inhibitor of metalloproteinases 2 (TIMP-2) and insulinlike growth factor binding protein 7 (IGFBP7) could be used for staging.

Objective

To test whether higher levels of urinary [TIMP-2] × [IGFBP7] are associated with lower survival among patients with the same functional stage of AKI.

Design, setting, and participants

This cohort study was performed using data from the Protocolized Care for Early Septic Shock (ProCESS) trial, which enrolled critically ill patients with septic shock who presented at academic and community emergency departments and intensive care unit

SUBMITTER: Molinari L 

PROVIDER: S-EPMC9118077 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature