Ontology highlight
ABSTRACT:
SUBMITTER: Janota CS
PROVIDER: S-EPMC9120458 | biostudies-literature | 2022 May
REPOSITORIES: biostudies-literature
Janota Cátia Silva CS Pinto Andreia A Pezzarossa Anna A Machado Pedro P Costa Judite J Campinho Pedro P Franco Cláudio A CA Gomes Edgar R ER
Nature communications 20220519 1
Nuclear position is central to cell polarization, and its disruption is associated with various pathologies. The nucleus is moved away from the leading edge of migrating cells through its connection to moving dorsal actin cables, and the absence of connections to immobile ventral stress fibers. It is unclear how these asymmetric nucleo-cytoskeleton connections are established. Here, using an in vitro wound assay, we find that remodeling of endoplasmic reticulum (ER) impacts nuclear positioning t ...[more]