Dataset Information
COVID-19 & differential effects in twins: Insights from Placenta Pathology.
Ontology highlight
ABSTRACT: Introduction
COVID-19 has been associated with several adverse pregnancy outcomes, including perinatal loss. Differential effects of COVID-19 in a twin pregnancy may provide unique insights into virus-placental interactions. We present a case of perinatal loss of a female fetus with survival of the male co-twin in a pregnancy complicated by COVID-19 and premature delivery.Methods
Viral detection methods recommended by the NICHD task force were used to identify SARS-CoV-2 and its viral receptors in the placentas and fetal tissue (Antoun et al., 2020) [1] RESULTS: Compared with the surviving twin, we found a more severe intervillous necrosis and a relatively low detection of ACE2 membranous expression in the syncytiotrophoblasts of the female twin that succumbed.Discussion
The interactions of SARS-CoV-2 and ACE2 at the maternal fetal interface within the placenta may play a significant role in perinatal loss, and the effects of fetal sex and gestational age at time of infection need to be explored further.
SUBMITTER: Moriarty K
PROVIDER: S-EPMC9121647 | biostudies-literature | 2022 Jun
REPOSITORIES: biostudies-literature
Publications
COVID-19 & differential effects in twins: Insights from Placenta Pathology.
Placenta 20220520
<h4>Introduction</h4>COVID-19 has been associated with several adverse pregnancy outcomes, including perinatal loss. Differential effects of COVID-19 in a twin pregnancy may provide unique insights into virus-placental interactions. We present a case of perinatal loss of a female fetus with survival of the male co-twin in a pregnancy complicated by COVID-19 and premature delivery.<h4>Methods</h4>Viral detection methods recommended by the NICHD task force were used to identify SARS-CoV-2 and its ...[more]
