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Ultra-Sharp Nanowire Arrays Natively Permeate, Record, and Stimulate Intracellular Activity in Neuronal and Cardiac Networks.

ABSTRACT: We report innovative scalable, vertical, ultra-sharp nanowire arrays that are individually addressable to enable long-term, native recordings of intracellular potentials. Stable amplitudes of intracellular potentials from 3D tissue-like networks of neurons and cardiomyocytes are obtained. Individual electrical addressability is necessary for high-fidelity intracellular electrophysiological recordings. This study paves the way toward predictive, high-throughput, and low-cost electrophysiological drug screening platforms.

SUBMITTER: Liu R

PROVIDER: S-EPMC9122115 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature

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Ultra-Sharp Nanowire Arrays Natively Permeate, Record, and Stimulate Intracellular Activity in Neuronal and Cardiac Networks.

Liu Ren R Lee Jihwan J Tchoe Youngbin Y Pre Deborah D Bourhis Andrew M AM D'Antonio-Chronowska Agnieszka A Robin Gaelle G Lee Sang Heon SH Ro Yun Goo YG Vatsyayan Ritwik R Tonsfeldt Karen J KJ Hossain Lorraine A LA Phipps M Lisa ML Yoo Jinkyoung J Nogan John J Martinez Jennifer S JS Frazer Kelly A KA Bang Anne G AG Dayeh Shadi A SA

Advanced functional materials 20211106 8

We report innovative scalable, vertical, ultra-sharp nanowire arrays that are individually addressable to enable long-term, native recordings of intracellular potentials. Stable amplitudes of intracellular potentials from 3D tissue-like networks of neurons and cardiomyocytes are obtained. Individual electrical addressability is necessary for high-fidelity intracellular electrophysiological recordings. This study paves the way toward predictive, high-throughput, and low-cost electrophysiological ...[more]

PMID: 35603230

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