Effect of Ethyl Acetate Fraction from Eucommia ulmoides Leaves on PM_2.5-Induced Inflammation and Cognitive Dysfunction.

ABSTRACT: This study aimed to evaluate the protective effect of the ethyl acetate from Eucommia ulmoides leaves (EFEL) on PM_2.5-induced cognitive impairment in BALB/c mice. EFEL improved PM_2.5-induced cognitive decline by improving spontaneous alternative behavioral and long-term memory ability. EFEL increased ferric reducing activity power (FRAP) in serum. In addition, EFEL increased superoxide dismutase (SOD) and reduced glutathione (GSH) contents and inhibited the production of malondialdehyde (MDA) in lung and brain tissues. EFEL also restored the mitochondrial function by regulating reactive oxygen species (ROS) production, mitochondrial membrane potential (MMP) level, and ATP level in lung and brain tissues. EFEL ameliorated the cholinergic system by regulating the

SUBMITTER: Kim MJ 

PROVIDER: S-EPMC9124148 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature