Paraventricular hypothalamic vasopressin neurons induce self-grooming in mice.

ABSTRACT: Self-grooming plays an essential role in hygiene maintenance, thermoregulation, and stress response. However, the neural populations involved in self-grooming remain largely unknown. The paraventricular hypothalamic nucleus (PVH) has been implicated in the regulation of self-grooming. Arginine vasopressin-producing neurons are among the major neuronal populations in the PVH (PVH^AVP), which play important roles in water homeostasis, blood pressure regulation, feeding, and stress response. Here, we report the critical role of PVH^AVP neurons in the induction of self-grooming. Optogenetic activation of PVH^AVP neurons immediately induced self-grooming in freely moving mice. Chemogenetic activation of these neurons also increased time spent self-grooming. In cont

SUBMITTER: Islam MT 

PROVIDER: S-EPMC9125887 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature