Islet autoantibody positivity in an adult population with recently diagnosed diabetes in Uganda.

ABSTRACT:

Aims

This study aimed to investigate the frequency of islet autoantibody positivity in adult patients with recently diagnosed diabetes in Uganda and its associated characteristics.

Methods

Autoantibodies to glutamic acid decarboxylase-65 (GADA), zinc transporter 8 (ZnT8-A), and tyrosine phosphatase (IA-2A) were measured in 534 adult patients with recently diagnosed diabetes. Islet autoantibody positivity was defined based on diagnostic thresholds derived from a local adult population without diabetes. The socio-demographic, clinical, and metabolic characteristics of islet autoantibody-positive and negative participants were then compared. The differences in these characteristics were analysed using the x2 test for categorical data and the Kruskal Wallis test for continuous d

SUBMITTER: Kibirige D 

PROVIDER: S-EPMC9126391 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature