Coronary vasomotor dysfunction portends worse outcomes in patients with breast cancer.

ABSTRACT:

Background

Impaired MFR in the absence of flow-limiting CAD is associated with adverse events. Cardiovascular disease is an important cause of morbidity and mortality in patients with breast cancer. We sought to test the utility of MFR to predict outcomes in a cohort of patients with breast cancer.

Methods

We retrospectively studied consecutive patients with breast cancer or breast cancer survivors who underwent cardiac stress PET imaging from 2006 to 2017 at Brigham and Women's Hospital. Patients with a history of clinically overt CAD, LVEF < 45%, or abnormal myocardial perfusion were excluded. Subjects were followed from time of PET to the occurrence of a first major adverse cardiovascular event (MACE) and all-cause death.

Results

The final cohort included 87 patien

SUBMITTER: Divakaran S 

PROVIDER: S-EPMC9126993 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature