Does Neuroinflammation Underlie the Cognitive Changes Observed With Dietary Interventions?

ABSTRACT: Dietary interventions, such as calorie restriction and ketogenic diet, have been extensively studied in ageing research, including in cognitive decline. Epidemiological studies indicate beneficial effects of certain dietary regimes on mental health, including mood disorders and dementia. However, randomised-controlled trials (the gold-standard of evidence-based medicine) on calorie restriction diets and the ketogenic diet have yet to show clinically convincing effects in neuropsychiatric disorders. This review will examine the quality of studies and evidence base for the ketogenic and calorie restriction diets in common neuropsychiatric conditions, collating findings from preclinical experiments, case reports or small clinical studies, and randomised controlled clinical trials. The major c

SUBMITTER: Robbins JP 

PROVIDER: S-EPMC9127342 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature