Renin-Angiotensin-Aldosterone System Activation and Diuretic Response in Ambulatory Patients With Heart Failure.

ABSTRACT:

Rationale & objective

Heart failure treatment relies on loop diuretics to induce natriuresis and decongestion, but the therapy is often limited by diuretic resistance. We explored the association of renin-angiotensin-aldosterone system (RAAS) activation with diuretic response.

Study design

Observational cohort.

Setting & population

Euvolemic ambulatory adults with chronic heart failure were administered torsemide in a monitored environment.

Predictors

Plasma total renin, active renin, angiotensinogen, and aldosterone levels. Urine total renin and angiotensinogen levels.

Outcomes

Sodium output per doubling of diuretic dose and fractional excretion of sodium per doubling of diuretic dose.

Analytical approach

Robust linear regression models estimated

SUBMITTER: Amatruda JG 

PROVIDER: S-EPMC9127684 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature