Coronavirus disease 2019 vaccination is protective of clinical disease in solid organ transplant recipients.

ABSTRACT:

Background

Clinical effectiveness of coronavirus disease 2019 (COVID-19) vaccination in solid organ transplant recipients (SOTRs) is not well documented despite multiple studies demonstrating sub-optimal immunogenicity.

Methods

We reviewed medical records of eligible SOTRs at a single center to assess vaccination status and identify cases of symptomatic COVID-19 from January 1 to August 12, 2021. We developed a Cox proportional hazards model using the date of vaccination and time since transplantation as a time-varying covariate with age and gender as potential time-invariant confounders. Survival curves were created using the parameters estimated from the Cox model.

Results

Among 1904 SOTRs, 1362 were fully vaccinated (96% received mRNA vaccines) and 542 were either

SUBMITTER: Aslam S 

PROVIDER: S-EPMC9131390 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature