Covalent cannabinoid receptor ligands - structural insight and selectivity challenges.
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ABSTRACT:
SUBMITTER: Liddle I
PROVIDER: S-EPMC9132230 | biostudies-literature | 2022 May
REPOSITORIES: biostudies-literature
Publications
Covalent cannabinoid receptor ligands - structural insight and selectivity challenges.
Liddle Ian I Glass Michelle M Tyndall Joel D A JDA Vernall Andrea J AJ
RSC medicinal chemistry 20220404 5
X-ray crystallography and cryogenic electronic microscopy have provided significant advancement in the knowledge of GPCR structure and have allowed the rational design of GPCR ligands. The class A GPCRs cannabinoid receptor type 1 and type 2 are implicated in many pathophysiological processes and thus rational design of drug and tool compounds is of great interest. Recent structural insight into cannabinoid receptors has already led to a greater understanding of ligand binding sites and receptor ...[more]
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