Therapeutic anticoagulation using heparin in early phase severe coronavirus disease 2019: A retrospective study.

ABSTRACT:

Background

Although several reports recommend the use of systemic anticoagulation therapy in patients with severe coronavirus disease 2019 (COVID-19) pneumonia, appropriate target population and timing of administration are unknown. We assessed association between therapeutic anticoagulation administration with unfractionated heparin and outcomes in patients with severe COVID-19 pneumonia, assuming that anticoagulant administration effects are influenced by therapy timing.

Methods

This retrospective observational study included severe COVID-19 patients requiring mechanical ventilation in a tertiary emergency critical care hospital intensive care unit (ICU) in Japan from May 1, 2020 to September 30, 2021. All included patients were divided into early and late-phase administra

SUBMITTER: Takayama W 

PROVIDER: S-EPMC9135498 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature