The stem cell quiescence and niche signaling is disturbed in the hair follicle of the hairpoor mouse, an MUHH model mouse.

ABSTRACT:

Background

Hair follicle stem cells (HFSC) play an essential role in the maintenance of hair homeostasis; during the hair cycle, HFSC remain quiescent for most of its duration. The hairpoor mouse (+ /Hr^Hp), an animal model of Marie-Unna hypotrichosis (MUHH), overexpresses hairless in the bulge, inner root sheath, and outer root sheath of HF and shows the same phenotype as in MUHH patients manifesting sparse hair with progression to alopecia with age. The aim of this study was to gain an understanding of the hair cycle and the status of HFSC during the hair cycle of the hairpoor mouse in order to delineate the pathogenesis of MUHH.

Methods

H&E staining was performed in order to define the state of the hair follicle. FACS analysis and immunostaining were performed a

SUBMITTER: Choi K 

PROVIDER: S-EPMC9137081 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature